A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy

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A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy

The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that bu...

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Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study

BACKGROUND Skin allograft is the gold standard of wound coverage in patients with extensive burns; however, it is considered as a temporary wound coverage and rejection of the skin allograft is considered inevitable. In our study, skin allograft as a permanent coverage in deep burns is evaluated. METHODS Skin allograft survival was assessed in 38 patients from March 2009 to March 2014, retro...

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Bioresorbable scaffold as a dermal substitute.

INTRODUCTION Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE To assess the efficiency of a porous bio...

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A novel device to create consistent deep dermal burns in a porcine model.

We conducted this study to evaluate a novel device to create a consistent and reproducible deep partial thickness burn in a porcine model. A thermostatically controlled, heated aluminium disc device was fashioned by the Biomedical Department of our institution. Contact burns were made on the flank of two Great White pigs by applying the device heated to 92°C at intervals of 5, 10, 15 and 20 sec...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2016

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2016.4866